IL-1 and T Helper Immune Responses

IL-1 and T Helper Immune Responses

CD4 T cells play a critical role in mediating adaptive immunity to a variety of pathogens as well as in tumor immunity. If not adequately regulated, CD4 T cells can be also involved in autoimmunity, asthma, and allergic responses. During TCR activation in a particular cytokine milieu, naïve CD4 T cells may differentiate into one of several lineages of T helper (Th) cells, including Th1, Th2, an...

listeria monocytogenes protein fraction induces dendritic cells maturation and t helper 1 immune responses.

fully mature dendritic cells (dcs) play pivotal role in inducing immune responses and converting naïve t lymphocytes into functional th1 cells. we aimed to evaluate listeria monocytogenes-derived protein fractions to induce dc maturation and stimulating t helper (th)1 immune responses. in the present study, we fractionated listeria monocytogenes-derived proteins by adding of ammonium sulfate in...

Blocking IL-10 enhances bacillus Calmette-Guérin induced T helper Type 1 immune responses and anti-bladder cancer immunity

Proper induction of Th1 immunity is required for effective immunotherapy of bladder cancer with the bacillus Calmette-Guérin (BCG). Interleukin-10 (IL-10) downregulates the Th1 immune response and is associated with BCG therapy failure. We evaluated BCG plus IL-10 blocking antibodies and found that this combination therapy induces enhanced Th1 immune responses and anti-bladder cancer immunity i...

Fibroblast and T cells conditioned media induce maturation dendritic cell and promote T helper immune response

Dendritic cells (DCs) induce pathogen-specific T cell responses. We comprehensively studied the effects of addition of maturation stimulus, fibroblasts (fibroblast conditioned medium), PHA activated T cells (T cell conditioned medium), and mixture of fibroblast & PHA activated T cells (FCM-TCCM) conditioned media on maturation of DCs. Monocytes were cultured with GM-CSF and IL-4 for five days. ...

1 T Helper Type 17 Immune Response